Vascular Biology

Cardiovascular diseases (CVD) cause more deaths per year than the next six leading causes of death combined. There is also strong evidence for a role of oxidative stress, a key focus at Oxford Biomedical Research, in the development of CVD. Emerging risk factors for CVD include isoprostanes, C-reactive proteins, fibrinogen and plasminogen activator inhibitor 1 (PAI-1). Fibrinogen and PAI-1 are key components of the highly regulated coagulation process. Elevated PAI-1 transcription has been reported to be caused by oxidative stress activation of the AP-1 response element. Vascular endothelial cells also play a key role in cancer by limiting the access of circulating cells to sub-endothelial space and thereby reducing tumor metastasis.

We offer a wide range of antibodies, purified and recombinant proteins, and immunoassay kits for studies of proteins involved in cardiovascular biology – including those that play key roles in coagulation and its regulation, as well as other proteins that have been recognized as important in cardiovascular pathobiology.

Displaying 1-30 of 503 products
PRODUCT CATALOG # SIZE PRICEsort icon
Anti Human PAI-1 (non-inhibitory) PI60 1.0 mg $1,100.00
Anti Human PAI-1 PI63 1.0 mg $1,100.00
Anti Rat PAI-1 (inhibitory) Monoclonal Antibody PI65 1.0 mg $1,025.00
Human PAI-1 (Glycosylated - Stable Mutant) PL75 0.5 mg $955.00
Human PAI-1 (Glycosylated - Active Form) PL76 0.5 mg $955.00
Human PAI-1 (Glycosylated - Latent Form) PL77 0.5 mg $955.00
Human PAI-1 N-Terminal, Alexa Fluor 488 Labeled (Stable Mutant) PL78 0.5 mg $955.00
Human PAI-1 N-Terminal, Alexa Fluor 488 Labeled (Active Wild Type) PL79 0.5 mg $955.00
Human PAI-1 N-Terminal, Alexa Fluor 488 Labeled (Latent Wild Type) PL80 0.5 mg $955.00
Human PAI-1 (N-terminal Alexa Fluor 594 labeled stable mutant) UP50 0.5 mg $955.00
Human PAI-1 (N-terminal Alexa Fluor 594 labeled, active fraction) UP51 0.5 mg $955.00
Human PAI-1 (N-terminal Alexa Fluor 594 labeled, latent fraction) UP52 0.5 mg $955.00
Human Vitronectin (monomeric) GP01 0.5 mg $875.00
Mouse Factor IX CF13 0.05 mg $850.00
Mouse Factor X CF38 0.1 mg $725.00
Rat Factor X CF42 0.1 mg $700.00
Anti Murine tPA PA62 1.0 mg $700.00
Anti Murine tPA PA63 1.0 mg $700.00
Anti Murine uPA (capture) PA70 1.0 mg $700.00
Anti Murine uPA PA71 1.0 mg $700.00
Human PAI-1 (active wild type) PI01 0.5 mg $700.00
Human PAI-1 (latent wild type) PI02 0.5 mg $700.00
Human PAI-1 (substrate form) P14 Arg PI04 0.5 mg $700.00
Human PAI-1 (stable mutant) PI05 0.5 mg $700.00
Human PAI-1 (6-X His Tag) PI06 0.5 mg $700.00
PAI-1 mutant - minimal vitronectin binding PI07 0.5 mg $700.00
Human PAI-1 (NBD P9 mutant) PI09 0.5 mg $700.00
PAI-1 mutant reports vitronectin binding PI10 0.5 mg $700.00
Human PAI-1 (pancreatic elastase inhibitor) PI11 0.5 mg $700.00
Human PAI-1 (Cathepsin G inhibitor) PI12 0.5 mg $700.00
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